Two simple methods to predict Pediatric Dose of Antituberculosis Medicines: Application of Allometry and Salisbury Rule

• DOI: 10.36922/jctr.24.00070
• Publication Date: 2025-03-06T01:27:26Z
• Authors: Iftekhar Mahmood
• Keywords: Allometry

Background: In drug development, selecting the first-in-human dose is crucial. Similarly, in pediatric determining first-in-pediatric of paramount importance. Given that pharmacokinetic, safety, and efficacy a product are generally well established adults, this information can be used to select an appropriate for clinical trials. Methods: Two simple methods – Salisbury Rule allometric scaling were evaluated predicting initiate trial antituberculosis medicines. To assess predictive performance these methods, predicted doses compared with observed recommended by World Health Organization (WHO) or United States Food Drug Administration (US FDA). Results: This study included seven drugs 62 observations across different body weight groups. The accuracy both was excellent, over 80% falling within 30% prediction error. Conclusion: using two proposed reconciled human from WHO US FDA. easily calculated on spreadsheet calculator short amount time. Relevance patients: These approaches helpful optimizing selection medication dosages patients tuberculosis, ensuring effective treatment, minimizing potential risks.