Clinical safety of zafirlukast treatment during a foreign body inflammatory reaction in nile tilapias, oreochromis niloticus

• DOI: 10.37118/ijdr.22149.06.2021
• Publication Date: 2021-07-09T14:14:10Z
• Authors: Susana Luporini D...; Mayumi Fernanda A...; Letícia Rodrigues; Camila Carlino da...; Gabriel Conde; Alessandra Cristi...; Wilson Gómez Manr...; Ives Charlie‐Silva; Marco Antônio de ...; Fernanda Aracati; Ives Charlie; Marco Antonio; Andrade Belo
• Keywords: Nile tilapia

Seeking to understand the defense mechanisms of tilapia assist in sanitary management fish farms, this study aimed evaluate clinical safety Nile (Oreochromis niloticus) submitted oral treatment with 500μg zafirlukast/Kg body weight during chronic inflammation, through implantation round glass coverslips subcutaneous tissue. For study, 63 male tilapiawere randomly distributed 9 aquariums compose following treatments: Control inflammatory stimulus without treatment; CT – Conventional PT Prolonged treatment. Seven animals were evaluated per three periods: 2, 4 and 8 days post-implantation (DPI).Tilapia foreign reaction showed a decrease erythrocyte counts hematocrit values, as well macrocytic changes, these effects mitigated by zafirlukast. gradual increase over time serum values total protein, cholesterol, triglycerides. Serum ALT, AST alkaline phosphatase control an late phase process (8 DPI). Therefore, it was possible conclude that treated 500µg zafirlukast attenuation hematological changes resulting from fluid-electrolyte imbalance ameliorated biochemical disorders, demonstrating cys-leukotriene blocker.