Synthesis and Chemical Characterisation of Some Novel Substituted Flavone’s for It’s Anti Microbial Activity

• DOI: 10.37285/ijddd.2.2.9
• Publication Date: 2024-12-09T13:58:36Z
• Authors: Mohamed Halith A.S.; Sivakumar T

The present study reports an experiment on some derivatives of 2-phenyl-chromen-4-one (flavone ring) have a proven inhibitory activity against a variety of human pathogens, including antibiotic-resistant Gram-positive and Gram-negative bacteria and antifungal activities screened against four human pathogenic bacteria and two phytopathogenic fungi. Flavanoid derivatives have been made through Algar– Flynn–Oyamada reaction from hydroxyacetophenones and aromatic-aldehydes. The structures of the synthesized compounds were elucidated by UV, IR and 1H NMR spectroscopic techniques, and elemental analysis. These compounds are potentially useful pharmacologically active compounds and are studied for biological activities like antibacterial and antifungal screens performed in vitro by the plate-hole diffusion method.