Formulation and In-Vitro Characterization of Olmesartan Medoxomil-Loaded Polymeric Nanoparticles

• DOI: 10.37285/ijpsn.2025.18.1.3
• Publication Date: 2025-03-09T15:58:18Z
• Authors: Amsa Palaniyappan; Sumathi Rajamani; Mohan Kumar Pandiyan; Nandhakumaran Jaw...; Tamizharasi Sengodan; Sivakumar Thangavel
• Keywords: Olmesartan; Characterization

Introduction: The antihypertensive drug Olmesartan Medoxomil has low oral bioavailability (28%) because it is poorly soluble in water, pre-systemic metabolism, and p-glycoprotein mediated efflux. Objective: goal of current investigation was to design loaded polymeric nanoparticles enhance through administration by using a solvent evaporation technique. Methods: formulation comprises ethyl cellulose, polyvinyl alcohol, Tween 80 as polymer, co-polymer, surfactant different concentrations were assessed for particle dimensions, surface charge, entrapment efficiency, polymer interactions, powder XRD, vitro study. Result: result the study shows size 92.02 nm, Poly Dispersibility Index 0.167, Zeta Potential −17.2 mV, Entrapment Efficiency 94%, release 89.21%. Conclusion: It concluded that promising approaches vehicle delivery remarkable increase solubility enhanced bioavailability.