Formulation and In-Vitro Characterization of Olmesartan Medoxomil-Loaded Polymeric Nanoparticles

DOI: 10.37285/ijpsn.2025.18.1.3 Publication Date: 2025-03-09T15:58:18Z
ABSTRACT
Introduction: The antihypertensive drug Olmesartan Medoxomil has low oral  bioavailability (28%) because it is poorly soluble in water, pre-systemic metabolism,  and p-glycoprotein mediated efflux.   Objective: The goal of current investigation was to design Olmesartan Medoxomil loaded polymeric nanoparticles to enhance bioavailability through oral  administration by using a solvent evaporation technique.   Methods: The formulation comprises ethyl cellulose, polyvinyl alcohol, and Tween  80 as polymer, co-polymer, and surfactant using different concentrations and were  assessed for particle dimensions, surface charge, entrapment efficiency, drug polymer interactions, powder XRD, and in vitro study.   Result: The result of the study shows particle size 92.02 nm, Poly Dispersibility Index  0.167, Zeta Potential −17.2 mV, Entrapment Efficiency 94%, and release of drug  89.21%.   Conclusion: It was concluded that Olmesartan Medoxomil nanoparticles shows  promising approaches as a vehicle for the oral drug delivery because of a  remarkable increase in solubility and enhanced bioavailability.
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