Reactive oxygen species in cancer progression and its role in therapeutics

• DOI: 10.37349/emed.2022.00073
• Publication Date: 2022-02-22T07:57:55Z
• Authors: Ranjeet Singh; Partha Pratim Manna
• Keywords: Cell Signaling

The redox status in pathogenesis is critically regulated by careful balance between the generation of reactive oxygen species (ROS) and their elimination. Increased ROS level above cellular tolerability threshold results apoptotic or necrotic cell death. belongs to a group highly compounds that have evolved play key roles signaling pathways. It’s widely assumed reasonable amount essential for variety biological processes. Elevated levels are known cause various pathologic conditions like neurological disorders, cardiovascular conditions, inflammation, autoimmunity, cancer. well initiate assist progression tumor promoting proliferation survival cancer cells thus facilitates pro-tumorigenic microenvironment. As become more resilient effects manipulating drugs, increased antioxidant capacity attenuates susceptibility treatment. Excessive environmental stress, on other hand, can die. This review summarizes molecular mechanisms including role checkpoint inhibitors be harnessed develop effective therapeutic strategies targeting related