The Effect of Exercising on Oxidative Stress Status and Pain in a Valproic-acid Induced Model of Autism Possible relevance of oxytocin

• DOI: 10.37358/rc.17.9.5815
• Publication Date: 2020-02-21T12:42:28Z
• Authors: Iulia Antioch; Dana Ababei; Radu Lefter; Alin Ciobica; Cezar Honceriu; Veronica Bild
• Keywords: Malondialdehyde; Valproic Acid

In this report we will describe the effect of exercising (6 days, each day 3 separate training phases 5 minutes each, on an adapted treadmill at 1.0 m/s) oxidative stress status from temporal lobe (expressed through main parameters: superoxide dismutase (SOD), glutathione peroxidase (GPX) and malondialdehyde (MDA), as a marker lipid peroxidation) pain (as determined 2 specific behavioural tasks such hot plate test for supraspinal acute thermal intra abdominal Zymosan administration eliciting local inflammatory reaction following responses to visceral pain) in rat valproic-acid induced perinatal model autism, also trying emphasize possible implication oxytocin complex pathological picture. We demonstrated here increased status, result exercising, VPA mainly by significant decrease activity SOD (for exercised female rats), well GPX male rats, when compared non-exercised groups, fact that aforementioned series exercises did not resulted any changes perception models studied pain-related tasks, independent gender rats with autism.