Metabolic Analysis in Women with Polycystic Ovary Highlight Specific Biomarkers of Insulin Resistance

• DOI: 10.37358/rc.19.10.3644
• Publication Date: 2020-01-18T13:29:32Z
• Authors: Camelia Larisa Vo...; Adriana Fodor; Gabriela Román; Andrada Alina Mur...; Anca Daniela Fărcaș; Georgeta Inceu; Adriana Rusu; Carmen Emanuela G...
• Keywords: Carbohydrate Metabolism

The aim of the paper is to detect insulin resistance (IR) biomarkers via metabolomics. It important understand PCOS pathophysiology, diagnosis measures and, subsequently, improve treatment type and time IR in PCOS. In most cases, almost half women with have which triggered by inflammation, glucotoxicity lipotoxicity. this work was conducted a systematic review all papers that used metabolomics for detecting women. exclusion criteria were: reviews, study population bellow 18 years age, studies including animals articles not English, remaining 4 records. results from literature shown phosphatidylcholines were decreased when compared controls. Nonetheless, trans-2-hexenoylcoa, linoleic acid, leucine, myristic acid palmitic regarding lipid metabolism tyrosine, lysine, phenylalanine a-aminoadipic amino also corelated healthy or Lactate only increased metabolite related glucose Metabolic alteration are controls those brought both IR. Lyso-phosphatidylcholine an pro-inflammatory altered signaling effect, alterations being considered hallmarks Serine hyperphosphorylation receptor accentuates decreasing receptor. Moreover, high levels lactate correlated may indicate muscle glycolysis, hepatic production peripheral uptake. evidenced technique. Keywords: Polycystic ovary syndrome, resistance, metabolomics, women, plasma, metabolism,