Analysis of Inclusion Complexes of Clotrimazole and Differently Substituted α, β and γ Cyclodextrins by NMR Spectroscopy

• DOI: 10.37358/rc.20.3.8024
• Publication Date: 2020-04-09T17:20:27Z
• Authors: Hajnal Kelemen; Bela Noszal; Gabor Orgovan
• Keywords: Clotrimazole; Imidazole; Stoichiometry; Inclusion compound; Proton NMR

Clotrimazole, a widely used imidazole-type antifungal agent and its cyclodextrin complexes were studied. Stoichiometries, structures stability constants of the inclusion with fourteen different derivatives characterized using NMR spectroscopy as primary technique. The found to be high (logK ] 2). 2D ROESY spectra revealed formation isomeric every highest constant was observed sulfobutylated β-CD, interestingly enough heptakis(2,3,6-tri-O-methyl)-β-cyclodextrin showed lowest stability.