Correlation between expression and differentiation of endocan in colorectal cancer

• DOI: 10.3748/wjg.14.4562
• Publication Date: 2008-08-07T10:42:58Z
• Authors: Li Zuo; Su-Mei Zhang; Ruo-Lei Hu; Hua-Qing Zhu; Qing Zhou; Shu-Yu Gui; Qiang Wu; Yuan Wang
• Keywords: Tissue microarray

AIM:To investigate the expression frequency of endocan in colorectal cancer and analyze relationship between clinical parameters to study role carcinogenesis.METHODS: Expression 72 tumor tissue samples as well 27 normal mucous membrane was analyzed using situ hybridization, immunohistochemistry on microarray, Western blot reverse-transcript polymerase chain reaction (RT-PCR).RESULTS: The higher colon rectum than cancerous (mRNA = 92.6%,protein 36%), lower 70.4%,protein 36.1%).No correlation found staining intensity such sex, age, size TNM stage.However, positively correlated with differentiation cancer. CONCLUSION:The is downregulated cancer, suggesting that associated development