Selective internal radiation therapy segmentectomy: A new minimally invasive curative option for primary liver malignancies?

• DOI: 10.3748/wjg.v30.i18.2379
• Publication Date: 2024-05-11T07:22:03Z
• Authors: Riccardo Inchingolo; Francesco Cortese; Antonio Rosario P...; Fabrizio Acquafredda; Roberto Calbi; Riccardo Memeo; Fotis Anagnostopo...; Stavros Spiliopoulos
• Keywords: Ablative case; Curative treatment

Transarterial radioembolization or selective internal radiation therapy (SIRT) has emerged as a minimally invasive approach for the treatment of tumors. This percutaneous technique involves local, intra-arterial delivery radioactive microspheres directly into tumor. Historically employed palliative measure liver malignancies, SIRT gained traction over past decade potential curative option, mirroring increasing role segmentectomy. The latest update BCLC hepatocellular carcinoma guidelines recognizes an effective modality comparable to other local ablative methods, particularly well-suited patients where surgical resection ablation is not feasible. Radiation segmentectomy more approach, aiming deliver high-dose one three specific hepatic segments, while minimizing damage surrounding healthy tissue. Future research efforts in should prioritize optimizing dosimetry and refining super-selective administration radiospheres within designated segments.