Hepatocardiorenal syndrome in liver cirrhosis: Recognition of a new entity?

• DOI: 10.3748/wjg.v30.i2.128
• Publication Date: 2024-01-10T10:14:25Z
• Authors: Henry H L Wu; Amina Rakisheva; Arvind Ponnusamy; Rajkumar Chinnadurai
• Keywords: Cardiorenal syndrome; Liver disease

Emerging evidence and perspectives have pointed towards the heart playing an important role in hepatorenal syndrome (HRS), outside of conventional understanding that liver cirrhosis is traditionally considered sole origin a cascade pathophysiological mechanisms directly affecting kidneys this context. In absence established disease, cirrhotic cardiomyopathy may occur more frequently those with kidney disease. It specific form cardiac dysfunction characterized by blunted contractile responsiveness to stress stimuli altered diastolic relaxation electrophysiological abnormalities. Despite clinical description these potential cardiac-related complications liver, has been overlooked aspect circulatory HRS. Yet from physiological sense, temporality (prior onset) cardiorenal interactions HRS positive effects stemming portosystemic shunting demonstrated development progression patients. review, we discuss current concepts surrounding how influence HRS, systemic inflammation endothelial causing within setting. The will be discussed. For subgroup patients who receive shunting, dynamics following treatment reviewed. Continued research determine unknowns topic anticipated, hopefully further clarify intricacies liver-heart-kidney connection improve strategies for management.