Multivariate statistical analysis of clinicopathologic factors influencing survival of patients with bile duct carcinoma

• DOI: 10.3748/wjg.v8.i5.943
• Publication Date: 2015-11-23T02:09:49Z
• Authors: Ping He
• Keywords: Perineural invasion; Univariate analysis; Bile duct cancer; Bile Duct Carcinoma; Prognostic variable

To evaluate the influence of various clinicopathologic factors on survival patients with bile duct carcinoma after curative resection.A retrospective analysis was made for 86 cases treated from January 1981 to September 1995. Fifteen possibly influencing were selected. Independent variables first analyzed by univariate methods. Survival variable estimated method Kaplan and Meier. The that statistically significant included in a multivariate analysis, which confirmed using Cox stepwise proportion hazard model help SPSS 10.0 Windows software.The overall cumulative rate 72.6 % at 1 year, 32.4 3 years, 18.7 5 years. results showed major prognostic these histological type lesion, lymph node metastasis, pancreatic invasion, duodenal perineural macroscopic vessel involvement, resected surgical margin depth cancer invasion (P=0.02, 0.02, 0.004, 0.005, 0.01, 0.43, 0.03 0.04). Age, sex, location tumor, size lesions, hepatic not significantly associated prognosis (P>0.05). Pancreatic metastases three most important proportional hazards model.Pancreatic are resection.