[Effect of preoperative monocyte-lymphocyte ratio on prognosis of patients with resectable esophagogastric junction cancer].

• DOI: 10.3760/cma.j.issn.0253-3766.2017.03.004
• Publication Date: 2017-03-23
• Authors: Wenjie Zhou; Jun Wu; Xiaodong Li; Qi Wang; Xuefeng Ni; Jingting Jiang; Mei Ji; Changping Wu
• Keywords: Univariate analysis; Grading (engineering); Lymphovascular invasion; Radical surgery

Objective: To investigate the associations between various blood test parameters including MLR (monocyte-lymphocyte ratio) and prognosis in post-operative esophagogastric junction cancer patients. Methods: We retrospectively studied preoperative postoperative data of 309 patients who underwent radical surgery for cancer. The relationship MLR, neutrophil lymphocyte ratio (NLR), platelet-lymphocyte (PLR) overall survival (OS) was analyzed. Results: cutoff values MLR、NLR PLR were 0.201, 1.697 96.960, respectively. median OS 51.4 months all study group (n=309). with carcinoma associated gender, depth invasion, histological grade, TNM stage, NLR (P<0.05). tumor size, (both P<0.05). Univariate analysis showed that metastasis lymph nodes, pathological grading, nerve infiltration, lymphovascular staging, time Multivariate infiltration independent prognostic predictors (P<0.05), but not or NLR. Setting optimal cut-off value area under curve 0.603, significantly larger than Conclusions: Preoperative is a very useful predictor rescetion. MLR> 0.201 an risk factor cancer, PLR> 96.960 may predict poor risk.目的： 评价单核细胞淋巴细胞比值(MLR)对食管胃结合部癌手术患者预后评估的价值，并将MLR和中性粒细胞淋巴细胞比值(NLR)以及血小板淋巴细胞比值(PLR)与患者预后的关系进行比较。 方法： 回顾性分析309例经根治性手术治疗的食管胃结合部癌患者的临床资料，分析MLR、NLR和PLR与患者预后的关系。 结果： MLR、NLR和PLR判断食管胃结合部癌患者总生存时间的最佳截点值分别为0.201、1.697和96.960。全组309例患者的中位生存时间为51.4个月。食管胃结合部癌患者的MLR与患者的性别、浸润深度、病理分级、TNM分期、NLR和PLR有关(均P<0.05)，PLR与患者的肿瘤大小、TNM分期、NLR和MLR有关(均P<0.05)，NLR与患者的性别、肿瘤大小、TNM分期、PLR和MLR有关(均P<0.05)。单因素分析结果显示，肿瘤大小、浸润深度、转移淋巴结数目、病理分级、是否神经浸润、是否有脉管癌栓、TNM分期、PLR和MLR与患者的中位生存时间有关(均P<0.05)。多因素分析表明，TNM分期、神经浸润和MLR是影响食管胃结合部癌手术患者预后的独立因素(均P<0.05)；而PLR和NLR并非独立的预后因素(均P>0.05)。MLR的最佳截点值设为0.201时，得到的曲线下面积为0.603，明显高于PLR和NLR(均P<0.05)。 结论： 术前MLR是食管胃结合部癌手术患者非常有用的预测因子。术前MLR>0.201是食管胃结合部癌患者术后生存不良的因素，但若患者的PLR>96.960亦应考虑有预后不良的风险。.