Neuroprotection in glaucoma: present and future

• DOI: 10.3760/cma.j.issn.0366-6999.20123565
• Publication Date: 2024-01-16T17:50:48Z
• Authors: Shi-da CHEN; Lu WANG; Xiu-lan ZHANG
• Keywords: Retinal Ganglion Cells; Oxidative Stress; Protein Folding; Neuroprotective Agents; Brain-Derived Neurotrophic Factor; Humans; Apoptosis; Glaucoma; Ciliary Neurotrophic Factor; Axonal Transport; Receptors, N-Methyl-D-Aspartate; Mitochondria

Objective To review the updated research on neuroprotection in glaucoma, and summarize potential agents investigated so far. Data sources The data this were collected from PubMed Google Scholar databases published English up to September 2012, with keywords including glaucoma , retinal ganglion cells both alone combination. Publications past ten years selected, but important older articles not excluded. Study selection Articles about selected reviewed, those that are cited identified by search strategy judged relevant also included. Results Although lowering intraocular pressure is only therapy approved as being effective treatment of increasing numbers studies have discovered various mechanisms death neuroprotective strategies. These strategies target neurotrophic factor deprivation, excitotoxic damage, oxidative stress, mitochondrial dysfunction, inflammation, activation intrinsic extrinsic apoptotic signals, ischemia, protein misfolding. Exploring mechanism axonal transport failure, synaptic glial system stem cell used constitute promising areas future. Conclusions Neuroprotective continue be refined, future deep investment researching pathogenesis may provide novel practical tactics. Establishing a assess effects treatments further facilitate research.