The relationship between serum amyloid A and apolipoprotein A-I in high-density lipoprotein isolated from patients with coronary heart disease

• DOI: 10.3760/cma.j.issn.0366-6999.20130400
• Publication Date: 2024-01-16T17:44:09Z
• Authors: Dong-xue Wang; Hong Liu; Li-rong Yan; Ye-ping Zhang; Xiao-yuan Guan; Zhi-min Xu; You-hong Jia; Yi-shi Li
• Keywords: High-density lipoprotein

Background Alteration in the protein composition of high-density lipoprotein (HDL) has been proposed as a mechanism for development coronary heart disease (CHD). In HDL, an increase serum amyloid A (SAA) accompanying decrease apolipoprotein A-I (apoA-I) found during acute inflammation period. However, whether this phenomenon persists CHD patients, related to inflammation, is unknown. The purpose present study was explore relationship between SAA and apoA-I HDL isolated from patients. Methods Overall, 98 patients with confirmed stable 90 control subjects matched age gender were enrolled case-control study. Potassium bromide (KBr) density gradient ultracentrifugation used isolate plasma. levels samples detected by enzyme-linked immunosorbent assay kits. Pearson's correlation general linear models analysis. Results Compared controls, had significant amount ((14.21±8.44) μg/ml vs. (10.95±5.95) μg/ml, P =0.003) log (1.21±0.46 1.51±0.55, <0.00001). Differences independent age, body mass index (BMI), cholesterol (HDL-C), other factors. An independently statistically positive observed only group (β =2.0, =0.026). model, changes log(SAA), age2, gender, BMI HDL-C could explain 43% variance apoA-I. Conclusions This provides direct evidence first time that there indicating alteration HDL. question associated impairment functions requires further research.