Prevalence, risk factors, clinical course, and outcome of acute kidney injury in Chinese intensive care units: a prospective cohort study

• DOI: 10.3760/cma.j.issn.0366-6999.20132065
• Publication Date: 2024-01-16T15:13:15Z
• Authors: Ying WEN; Li JIANG; Yuan XU; Chuan-yun QIAN; Shu-sheng LI; Tie-he QIN; Er-zhen CHEN; Jian-dong LIN; Yuhang AI; Da-wei WU; Yu-shan WANG; Ren-hua SUN; Zhen-jie HU; Xiang-yuan CAO; Fa-chun ZHOU; Zhen-yang HE; Li-hua ZHOU; You-zhong AN; Yan KANG; Xiao-chun MA; Xiang-you YU; Ming-yan ZHAO; Xiu-ming XI; Bin DU
• Keywords: Rifle

Background Acute kidney injury (AKI) has been recognized as a major healthcare problem affecting millions of patients worldwide. However, epidemiologic data concerning AKI in China are still lacking. The objectives this study were to characterize defined by RIFLE criteria, assess the association with hospital mortality, and evaluate impact context other risk factors. Methods This prospective multicenter observational enrolled 3,063 consecutive from 1 July 2009 31 August 22 ICUs across mainland China. We excluded who admitted for less than 24 hours ( n =1623), younger 18 years =127), receiving chronic hemodialysis =29), renal transplantation =1) unknown reasons =28). There 1255 final analysis. was diagnosed classified according criteria. Results 396 (31.6%) had AKI, maximum class R, I, F 126 (10.0%), 91 (7.3%), 179 (14.3%) patients, respectively. Renal function deteriorated 206 (16.4%). In comparison non on ICU admission more likely progress (odds ratio OR ) 3.564, 95% confidence interval CI 1.706 - 7.443, P = 0.001], while 5.215, 2.798–9.719, <0.001) 13.316, 7.507–23.622, significantly higher probability deteriorating into failure class. adjusted hazard ratios 90-day mortality 1.884 group, 3.401 5.306 group. Conclusions prevalence high among critically ill Chinese ICUs. non-AKI R or I susceptibility progression F. criteria robust correlated well clinical deterioration mortality.