Diabetic bladder dysfunction

• DOI: 10.3760/cma.j.issn.0366-6999.20132407
• Publication Date: 2024-01-16T18:57:28Z
• Authors: Liu Guiming; Daneshgari Firouz
• Keywords: Polyuria; Urinary bladder disease

Objective To review studies on diabetic bladder dysfunction (DBD), a common and bothersome complication of diabetes mellitus. Data sources We performed search the English literature through PubMed. The key words used were “diabetes” “bladder dysfunction” or “cystopathy”. Our own data perspective are included in discussion. Study selection Studies containing relevant to DBD selected. Because limited length this article, we also referenced reviews that contain comprehensive amalgamations literature. Results classic symptoms decreased sensation, increased capacity, impaired emptying with resultant elevated post-void residual urine. However, recent clinical experimental evidence indicate strong presence storage problems such as urge incontinence diabetes. Recent animal models type 1 have revealed temporal effects diabetes, causing an early phase compensatory function later decompensated function. pathophysiology is multifactorial, including disturbances detrusor, urothelium, autonomic nerves, urethra. Polyuria hyperglycemia play important but distinctive roles induction causes significant hypertrophy stage whereas oxidative stress caused by chronic may role late failure Conclusions includes time-dependent mixed manifestations. pathological alterations include muscle, nerve, urothelium. independently contribute pathogenesis DBD. Treatments for limited. Future 2 should be investigated separately. Animal needed, from natural history mechanisms. Further understanding molecular mechanisms will provide multiple potential targets therapeutic intervention.