Protective effect of progesterone on rat optic nerve after optic nerve crush

• DOI: 10.3760/cma.j.issn.1006-4443.2017.08.022
• Publication Date: 2017-08-10
• Authors: Haiyan Sun; Sun Wenting; Guoyu An
• Keywords: Abdominal cavity; Crush injury

Objective To observe protective effect of progesterone on rat Optic Nerve after optic nerve crush.

Methods Fifty female SD rats were randomly divided into three groups, normal group with 10 (20 eyes, the had no treatment), control 20 and treatment rats. Mis-classification damage analogues made treated group. For group, was injected to rats’ abdominal cavity (10mg/kg) one hour injury, for once a day until end experiment. distilled water Four retinas every taken. Fixed, embedded, sliced HE staining morphological changes retina detect mean OD value IGF-1 AQP-4.

Results The expression in enhanced significantly 1 day, 3 days 7days injury (P <0.05) began decrease at 14th day.The expressions obvious than that time point there significant difference between two <0.05). The AQP-4 increase reached highest level third 7th closed 28th day. Except positive first 3rd lower control.

Conclusions The retinal tissue is it increases incomplete nerve. participate process Progesterone can promote regeneration repair cell.

Key words: Optic nerve; Progesterone; Retina ganglion cell; Insulin-like growth factor-1; Aquaporin-4