Mechanisms of pulmonary embolism and/or deep vein thrombosis secondary to chronic obstructive pulmonary disease exacerbation in elders

• DOI: 10.3760/cma.j.issn.1671-7368.2014.06.007
• Publication Date: 2014-06-04
• Authors: Jiu‐Wu Bai; Beilan Gao; Jin‐Fu Xu; Huiping Li; Weijun Cao; Shuo Liang; Kebin Cheng; Hai‐Wen Lu
• Keywords: Erythrocyte sedimentation rate; D-dimer

Objective To explore the inflammatory mechanisms of pulmonary embolism (PTE) and/or deep venous thrombosis (DVT) in elders secondary to chronic obstructive disease (COPD) exacerbation.

Methods A total 26 with acute exacerbation high-risk COPD PTE DVT and patients low-risk during stable phase diagnosed period January 2008 December 2012 were enrolled. The relevant parameters routine blood examination, viscosity, D-dimer, fibrinogen (FIB), arterial gas, cytokine, erythrocyte sedimentation rate (ESR) C-reactive protein (CRP) retrospectively analyzed.

Results The major nonspecific symptoms cough, sputum dyspnea. mean neutrophile percentage (N%), FIB, interleukin-6 (IL-6), tumor necrosis factor (TNF), (CRP), low high shear viscosity samples (or) higher than those control group (t=3.339, 2.700, 2.207, 2.431, 2.257, 2.143, 2.223, 2.797, all P<0.05). However partial pressure oxygen (PaO2) was lower that lower-risk (t=4.312, IL-6 positively correlated low-shear D-dimer FIB (r=0.437, 0.624, 0.429, TNF cut (r=0.624, 0.519, 0.513, Plasma CRP (r=0.478, 0.541, 0.533, 0.491, P<0.05).

Conclusions Inflammation may exist thrombotic disease. promote Early screening prophylactic anticoagulation are necessary for prevention.

Key words: Pulmonary disease, obstructive; Pulmonary embolism; Venous