The effect of atorvastatin combined with insulin glargine on renal function in patients with early diabetic nephropathy

• DOI: 10.3760/cma.j.issn.1673-4904.2020.02.005
• Publication Date: 2020-02-05
• Authors: Haiyan Shen; Xiangdong Li; Yi Li; Ming Zhao; Ying Zhai; Bohui Guo; Qingjuan Chen

Objective To observe the effect of atorvastatin combined with insulin glargine on renal function in patients early diabetic nephropathy.

Methods From January 2016 to March 2019, 100 nephropathy admitted Hanzhong 3201 Hospital Affiliated Xi′an Jiaotong University Medical School were selected as subjects. According random number table, divided into control group and observation group, 50 cases each group. All underwent diet control, blood pressure symptomatic treatment. Patients treated glucose. given this basis. After 16 weeks treatment, therapeutic effects two groups observed, well change urinary albumin excretion rate (UAER), serum creatinine (Scr), C-reactive protein (CRP), total cholesterol (TC), triglyceride (TG). Adverse reactions observed during treatment both groups.

Results After levels UAER, Scr, CRP, TC TG lower than those before above indexes The difference statistically significant (P 0.05).

Conclusions Atorvastatin can effectively reduce TG, has good safety.

Key words: Diabetic nephropathy; Atorvastatin; Insulin glargine; Treatment outcome; Renal