Detonation nanodiamonds biofunctionalization and immobilization to titanium alloy surfaces as first steps towards medical application

• DOI: 10.3762/bjoc.10.293
• Publication Date: 2014-11-26T09:45:40Z
• Authors: Juliana P L Gonça...; Afnan Q Shaikh; Manuela Reitzig; Daria A Kovalenko; Jan Michael; René Beutner; Gianaurelio Cunib...; Dieter Scharnweber; Jörg Opitz
• Keywords: titanium alloy; Science; biofunctionalization; Q; Organic chemistry; electrochemical immobilization; 01 natural sciences; Full Research Paper; 3. Good health; 0104 chemical sciences; QD241-441; carbon-nanomaterials; detonation nanodiamond; surface modification

Due to their outstanding properties nanodiamonds are a promising nanoscale material in various applications such as microelectronics, polishing, optical monitoring, medicine and biotechnology. Beyond the typical diamond characteristics like extreme hardness or high thermal conductivity, they have additional benefits intrinsic fluorescence due lattice defects without photobleaching, obtained during pressure temperature process. Further carbon surface its functional groups consequence of synthesis, facilitate chemical biological modification. In this work we present our recent results on modification nanodiamond with phosphate electrochemically assisted immobilization titanium-based materials increase adhesion at biomaterial surfaces. The starting is detonation nanodiamond, which exhibits heterogeneous resulting from nitrogen-rich explosives subsequent purification steps after synthesis. Nanodiamond surfaces chemically homogenized before proceeding further functionalization. Suspensions surface-modified applied titanium alloy subsequently fixed by electrochemical immobilization. Titanium alloys been widely used bone dental implants for being metal that biocompatible body tissues able bind adjacent healing. order improve towards biomedical authors aim incorporating into implant surface, namely anodically grown dioxide layer. Differently functionalized characterized infrared spectroscopy modified scanning transmission electron microscopy. process described shows an adsorption titanium; where aminosilanized coupled O-phosphorylethanolamine show homogeneous interaction substrate.