Antibacterial structure–activity relationship studies of several tricyclic sulfur-containing flavonoids

• DOI: 10.3762/bjoc.12.100
• Publication Date: 2016-05-23T16:19:44Z
• Authors: Lucian G Bahrin; Henning Hopf; Peter G Jones; Laura G Sarbu; Cornelia Babii; Alina C Mihai; Marius Stefan; Lucian M Birsa
• Keywords: Moiety; Tricyclic

A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have synthesized by cyclocondensation corresponding 3-dithiocarbamic flavanones under acidic conditions. influence different halogen substituents on tested against Staphylococcus aureus and Escherichia coli . Amongst N , -dialkylamino-substituted flavonoids, those having an -diethylamino moiety exhibited good to excellent antimicrobial both pathogens. Fluorine-substituted were found be less active than bearing other atoms.