Antibacterial structure–activity relationship studies of several tricyclic sulfur-containing flavonoids

Moiety Tricyclic
DOI: 10.3762/bjoc.12.100 Publication Date: 2016-05-23T16:19:44Z
ABSTRACT
A structure–activity relationship study concerning the antibacterial properties of several halogen-substituted tricyclic sulfur-containing flavonoids has been performed. The compounds have synthesized by cyclocondensation corresponding 3-dithiocarbamic flavanones under acidic conditions. influence different halogen substituents on tested against Staphylococcus aureus and Escherichia coli . Amongst N , -dialkylamino-substituted flavonoids, those having an -diethylamino moiety exhibited good to excellent antimicrobial both pathogens. Fluorine-substituted were found be less active than bearing other atoms.
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