α,ß-Didehydrosuberoylanilide hydroxamic acid (DDSAHA) as precursor and possible analogue of the anticancer drug SAHA

• DOI: 10.3762/bjoc.15.245
• Publication Date: 2019-10-24T06:08:00Z
• Authors: Shital K Chattopa...; Subhankar Ghosh; Sarita Sarkar; Kakali Bhadra
• Keywords: HeLa; Hydroxamic acid; Derivative (finance); Anticancer drug; Alkene; Moiety

An alternate synthetic route to the important anticancer drug suberoylanilide hydroxamic acid (SAHA) from its α,ß-didehydro derivative is described. The didehydro obtained through a cross metathesis reaction between suitable terminal alkene and N -benzyloxyacrylamide. Some of derivatives SAHA were preliminarily evaluated for activity towards HeLa cells. administration analogues caused significant decrease in proliferation Furthermore, one showed maximum cytotoxicity with minimum GI 50 value 2.5 µg/mL generation reactive oxygen species (ROS) as some apoptotic features.