Efficient synthesis of β’-amino-α,β-unsaturated ketones

• DOI: 10.3762/bjoc.9.52
• Publication Date: 2013-03-06T12:44:37Z
• Authors: Isabelle Abrunhos...; Aurélie Plas; Nishanth Kandepedu; Pierre Chalard; Yves Troin
• Keywords: Letter; Science; Q; Organic chemistry; β'-amino-α; Horner–Wadsworth–Emmons reaction; 01 natural sciences; 0104 chemical sciences; QD241-441; β-unsaturated ketones; Horner-Wadsworth-Emmons reaction; stereoselective synthesis; β’-amino-α,β-unsaturated ketones

A general and simple procedure to access chiral β'-amino-α,β-enones, in seven steps, from an α,β unsaturated ester has been described. The use of a Horner–Wadsworth–Emmons reaction as key step for generating the permits range substrates under mild conditions moderate high yield.