Microwave-Enhanced, Additive-Free C-H Amination of Benzoxazoles Catalysed by supported Copper
DOI:
10.3762/bxiv.2025.14.v1
Publication Date:
2025-03-04T15:43:36Z
AUTHORS (9)
ABSTRACT
The C2 amination of benzoxazole offers wide-ranging potential for substrate expansion and the functionalisation bioactive compounds. This study presents a green efficient C-H amination, catalysed by CuCl CuCl₂, in acetonitrile without acidic, basic or oxidant additives that is accelerated Microwave (MW) irradiation completed 1.5–2 h. A solid Cu(I) catalyst supported on aminated silica made process cost-effective heterogeneous, thus simplifying work-up minimising free copper solution. was found to be regenerable reusable up eight cycles. optimised method facilitated synthesis various derivatives, demonstrating its versatility practical applicability.
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