Does CA-125 have a Role in Early Diagnosis of Ovarian Malignancy in Non-Menopausal Women?

• DOI: 10.37871/jbres1454
• Publication Date: 2023-10-12T16:01:36Z
• Authors: Momen Zakaria El ...; Bahgat Korany Yas...; Hanan Hosni Mowad; Nesreen Abdelfatt...; Sara Abdallah Moh...
• Keywords: Adnexal mass; Cancer antigen; Cut-off

Objective: Aim of this study is to assess the role Cancer Antigen (CA-125) in detection ovarian malignancy premenopausal women with mass. Methods: This observational was carried out (blinded). It included 200 who had preliminary diagnosis adnexal mass whatever its nature. Adnexal masses were detected either clinically or by ultrasound. Results: The shows distribution different pathologies malignancy, stage at and benign spectrum investigated population. also reveals CA-125 cutoff point 35.1 sensitivity specificity reached 93.1% 92.2% respectively. Area under Curve (AUC) 0.998, Positive Prediction Value (PPV) 91.7% Negative (NPV) 92.1. Conclusion: According our results could be suitable as an cancer marker.