Diagnostic value of DWI-MRI for the detection of acute plaques in the relapse phase of multiple sclerosis

• DOI: 10.37897/rjn.2021.1.5
• Publication Date: 2021-06-21T10:10:14Z
• Authors: Mehran Yousefi; ; Mehdi Panahali; ; ; Kamran Azarkhish; ; ; Nazanin Azizi Sha...; ; ; Sajjad Biglari; ; ; Zahra Jor-Ahmad; ; ; Mehdi Maghbooli
• Keywords: Fluid-attenuated inversion recovery

Background. The 2010 revision of the McDonald criteria, widely used for diagnosis multiple sclerosis (MS), has established that dissemination in time (DIT) can be demonstrated by simultaneous presence asymptomatic gadolinium-enhancing and non-enhancing plaques on a single magnetic resonance imaging (MRI). When use gadolinium contrast agents is contraindicated, diffusion-weighted (DWI) utilized to confirm diffusion alterations active inflammatory plaques. This study intended examine whether DWI viable alternative contrast-enhanced T1-weighted demonstrating DIT MS. Material methods.We assessed 30 previously diagnosed MS patients during acute relapse (based criteria) evaluated their brain MRI via DWI‚ imaging, FLAIR sequences. Asymptomatic were defined as either hyperintense or non-hyperintense enhancing T1GAD-MRI. Statistical indices prediction plaque enhancement T1 GAD-MRI DWI-MRI calculated compared. Results. participants our had total 925 demyelinating larger than 3mm size presented FLAIR-MRI. Diffusion hyperintensity significantly correlated. sensitivity‚ specificity, positive predictive value‚ negative value, accuracy 69.66%‚ 99.76%‚ 96.88%‚ 96.86%, respectively. Conclusions. Hyperintense findings do not necessarily overlap with enhancements GAD-MRI. was shown produce higher rate false-positive results. Our concludes although should replaced determine due its lower DWI’s continued surrogate screening sequence whenever T1GAD-MRI concern without merits.