Systematic Development of Self-Emulsifying Drug Delivery Systems of Atorvastatin with Improved Bioavailability Potential

• DOI: 10.3797/scipharm.1201-06
• Publication Date: 2012-10-16T17:18:14Z
• Authors: Fariba Khan
• Keywords: Excipient

The aim of this study was to prepare and characterize a self-emulsifying drug delivery system (SEDDS) with high load poorly water-soluble atorvastatin for the enhancement dissolution oral bioavailability. Solubility in oil, surfactant, cosurfactant determined. Pseudo-ternary phase diagrams were constructed by aqueous titration method, formulations developed based on optimum excipient combinations. A (10% w/w) achieved combination oleic acid, Tween 80, polyethylene glycol 400, ensuring maximum property (in case SES6). Effects lipids surfactants physical properties SEDDS such as vitro emulsification efficiency terms self-emulsification time, emulsion droplet size, percent transmittance measured. Multiple regression analysis revealed that higher amount significantly increased ATV while decreasing size time. About four-fold increase compared pure powder. Overall, suggests bioavailability could be improved technology.