The risk of lymphedema after postoperative radiation therapy in endometrial cancer

• DOI: 10.3802/jgo.2016.27.e4
• Publication Date: 2015-12-09T03:17:26Z
• Authors: Devarati Mitra; Paul J. Catalano; Nicole Cimbak; Antonio L. Damato; Michael G. Muto; Akila N. Viswanathan
• Keywords: Gynecologic cancer

Lower extremity lymphedema adversely affects quality of life by causing discomfort, impaired mobility and increased risk infection. The goal this study is to investigate factors that influence the likelihood in patients with endometrial cancer who undergo adjuvant radiation or without chemotherapy. A retrospective chart review identified all stage I-III had a hysterectomy complete staging lymphadenectomy therapy between January 2006 February 2013. Patients new-onset after treatment were identified. Logistic regression was used find influenced risk. Of 212 met inclusion criteria, 15 (7.1%) developed lymphedema. Lymphedema associated lymph-node dissection (odds ratio [OR], 5.6; 95% CI, 1.01 105.5; p=0.048) presence pathologically positive lymph nodes (OR, 4.1; 1.4 12.3; p=0.01). Multivariate logistic confirmed association positivity 3.2; 1.0007 10.7; p=0.0499) when controlled for dissection. Median time onset 8 months (range, 1 58 months) resolution improvement eight (53.3%) median 10 months. Lymph-node an received radiation. Future studies are needed explore whether node-positive may benefit from early lymphedema-controlling interventions.