Acute and chronic Chlamydia pneumoniae infection and inflammatory markers in coronary artery disease patients

• DOI: 10.3855/jidc.1704
• Publication Date: 2011-08-12T05:36:54Z
• Authors: Mehvash Haider; Meher Rizvi; Abida Malik; Mohammad Azam; Mohammad Urooj Ra...
• Keywords: Unstable angina; Chlamydophila pneumoniae

Introduction: We evaluated the role of inflammation and acute or persistent Chlamydia pneumoniae infection in coronary artery disease (CAD). Methodology: The study involved 63 cardiovascular patients diagnosed with angina myocardial infarction (MI) 40 healthy controls. ELISA was performed for detection C. IgA antibodies quantitative analysis IFN-γ. PCR 16 SrRNA gene blood. Results: were detected 66.66% cases 41.37% Of seropositive 71.43% MI patients, 61.90% stable 64.29% unstable patients. whose done 32.5% positive which 76.92% seropositive. Traditional risk factors not significantly associated CAD. mean value IFN-γ 32.12pg/ml 11.32pg/ml Elevated observed seropositives a 3.39pg/ml, 12.91 pg/ml 23.89 pg/ml. levels who by serology 55.21 Conclusion: CAD risk. progression to adverse clinical outcome evident high percentage among positives. Although alone had play development CAD, its values further enhanced due recurrent infection.