Antibiotic susceptibility of Helicobacter pylori isolates in Dakar, Senegal

• DOI: 10.3855/jidc.512
• Publication Date: 2010-05-03T12:12:39Z
• Authors: Abdoulaye Seck; Mouhamadou Mbengue; Amy Gassama-Sow; Lamine Diouf; Mouhamadou Mourta...; Cheikh Saad-Bouh ...
• Keywords: Adult; 0301 basic medicine; Microbial Sensitivity Tests; antimicrobial susceptibility; Helicobacter Infections; 03 medical and health sciences; MESH: Senegal; Ciprofloxacin; MESH: Anti-Bacterial Agents; Metronidazole; MESH: Drug Resistance, Bacterial; Drug Resistance, Bacterial; Humans; MESH: Ciprofloxacin; Stomach Ulcer; MESH: Metronidazole; MESH: Microbial Sensitivity Tests; MESH: Humans; Helicobacter pylori; MESH: Helicobacter Infections; Amoxicillin; MESH: Adult; MESH: Amoxicillin; MESH: Stomach Ulcer; [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology; Senegal; Anti-Bacterial Agents; 3. Good health; MESH: Duodenal Ulcer; Duodenal Ulcer; MESH: Helicobacter pylori

Helicobacter pylori is the primary cause of peptic ulcer disease and an etiologic agent in the development of gastric cancer. A high frequency of H. pylori infection has been reported from resource-poor regions. H. pylori infection is curable with regimens of multiple antimicrobial agents. However, antibiotic resistance is a leading cause of treatment failure. In Africa, there are very little data concerning the susceptibility of H. pylori isolates to antibiotics.H. pylori isolates from gastric biopsies from outpatients > or = 18 years old affected by a gastro-duodenal ulcer were used in this study. Susceptibility testing was performed for amoxicillin, ciprofloxacin and metronidazole by using the Epsilometer test (E-test) method.H. pylori strains were isolated from 40 patients of whom 36 were diagnosed as having duodenal ulcer, two with gastric ulcer, and two with gastro-duodenal ulcer. Thirty-six (90%) of the isolates were resistant to metronidazole (MICs > or = 8 microg/l), whereas all isolates were susceptible to amoxicillin (MICs < or = 0.5 microg/ml) and ciprofloxacin (MICs < or = 1 microg/ml).These data suggest that metronidazole should not be used therapeutically among Senegalese patients in first-line therapy, while ciprofloxacin could be recommended in association with amoxicillin and a proton pump inhibitor in Senegal.