Predictive value of immunological markers in systemic sclerosis

• DOI: 10.3892/etm.2021.10426
• Publication Date: 2021-07-14T10:04:34Z
• Authors: Carmen Bobeica; Elena Niculet; Alina Halip; Laura Gheuca‑Solo...; Miruna Draganescu; Ioana Popescu; Cristian Onisor; Silvia Chirobocea; Mihaela Lungu; Mihaela Craescu
• Keywords: Scleroderma (fungus)

Systemic sclerosis (SSc) is a collagenosis characterized by excessive deposition of collagen in the skin and viscera, background immune disorder. The immunological profile SSc often shows elevated levels antinuclear antibodies (ANAs). However, many authors have identified cases having normal ANA levels, framed as paraneoplastic SSc. Among patients with negative ANAs our group, we did not identify any neoplastic process that could support this hypothesis. extended detection autoantibodies extremely useful establishing subset Thus, anti-Scl70 are specific for diffuse SSc, while anticentromere (ACAs) specificity limited subset. studies shown existence high titers ACAs antibodies. This indicates an inconsistent association between disease to each Our study found more balanced consistency subsets Therefore, percentages lower than those other authors. observation opens perspective larger on