Evaluation of clinical efficacy of tumor necrosis factor‑α inhibitors in treatment of distal extremity swelling with pitting edema in psoriatic arthritis of inadequate response to conventional therapy: A 10‑year retrospective study

• DOI: 10.3892/etm.2023.11962
• Publication Date: 2023-04-19T11:46:46Z
• Authors: Chenyang Zhao; Bingqian Liu; Yuan Yao; Kevin Yang; Bo Zang; Bin Liu
• Keywords: Erythrocyte sedimentation rate

Distal extremity swelling with pitting edema in psoriatic arthritis (PsA) is a rare rheumatological condition, whose management presents challenge. The aim of the present study was to identify clinical characteristics of, and formulate standardized strategy for, patients distal PsA. medical records consecutive PsA, or without edema, were systematically analyzed over ~10-year period (between September 2008 2018) single center comprehensive review (pathogenic mechanisms, manifestations, treatments) undertaken. A total 167 PsA evaluated, recorded 16 these patients. In three patients, occurred as first, isolated manifestation upper lower extremities affected, predominantly asymmetrically. Female more likely be affected blood test results revealed that also presented significantly higher erythrocyte sedimentation rate concentration C-reactive protein. onset associated activity disease. Lymphoscintigraphy magnetic resonance imaging (MRI) scans might have resulted from inflammation tenosynovial structures. Furthermore, treatment tumor necrosis factor-α inhibitor (TNFi) elicited improvements not responsive conventional synthetic disease-modifying antirheumatic drug therapy. conclusion, termed atypical remitting seronegative symmetrical synovitis (RS3PE) syndrome, may represent initial RS3PE syndrome attributable structures, TNFi serve potential treatment.