Decrease in lipid metabolic indexes in infants with neonatal respiratory distress syndrome

• DOI: 10.3892/etm.2023.12357
• Publication Date: 2023-12-19T13:00:10Z
• Authors: Guohong Zheng; Jiansheng Zheng; Xiangrong Hu; Tang Zhu
• Keywords: Bronchopulmonary Dysplasia

Incomplete pulmonary function and insufficient production of surfactant in premature infants may affect alveolar relaxation, inducing neonatal respiratory distress syndrome (NRDS). The present study was a retrospective comparison lipid metabolism indexes clinic information between NRDS non‑NRDS infants. Data on general information, pregnancy, clinical symptoms, family history as well plasma biochemical metabolic were retrospectively collected statistically analyzed from 79 patients with 44 Infants the group showed lower body weight (2,055 vs. 3,225 g) gestation age (33.39 38.53 weeks) than those (P<0.05). Baseline corrected by inverse probability treatment weighting (IPTW) analysis. weighted adjusted median same both groups there no significant difference two birth weight. IPTW analysis revealed that levels triglyceride (TG), total cholesterol, low‑density lipoprotein, free triiodothyronine, thyroxine, glucose, calcium (Ca²⁺) phosphorus significantly compared Additionally, had higher incidence rates pneumonia, sepsis, brain injury infection, preterm birth, patent foramen ovale, ductus arteriosus rupture membranes Multivariate logistic TG Ca²⁺ risk factors associated have indexes. results provide data to guide management NRDS.