Vascular endothelial cells of Mongolian gerbils are resistant to cholesterol-induced mitochondrial dysfunction and oxidative damage

• DOI: 10.3892/etm.2024.12645
• Publication Date: 2024-07-08T11:03:12Z
• Authors: Xiaobing Wang; Yuchen Dong; Hongjian Du; Yijia Lu; Yanjie Jiang; Mingxing Ding; Xiaosheng Sheng
• Keywords: Endothelial Dysfunction

Atherosclerosis is essentially the leading factor behind occurrences of cardiovascular diseases (CVDs)-associated incidents, while mitochondrial dysfunction also main cause atherosclerosis. The present study conducted a comparative analysis function-related indicators in cholesterol-induced vascular endothelial cells (VECs) from Mongolian gerbils, Sprague-Dawley (SD) rats and humans. It reported that inhibitory effect cholesterol treatment on viability gerbil VECs was markedly lower than other two types at same concentration. Following treatment, DNA copy numbers, reactive oxygen species level, calcium concentration membrane potential did not change markedly. These results suggested function mitochondria normal. Additionally, alter levels superoxide dismutase, glutathione peroxidase, ATP, NADH-CoQ reductase cytochrome c oxidase VECs. hypothesized gerbils have certain resistance to oxidative damage induced by cholesterol. In brief, demonstrated are resistant damage. aforementioned findings establish theoretical foundation for advancement innovative strategies prevention