Cholesteryl esters in human malignant neoplasms

• DOI: 10.3892/ijmm.11.1.95
• Publication Date: 2014-03-10T03:36:09Z
• Authors: M. Tosi; G. Bottura; P. Lucchi; A. Reggiani; A. Trinchero; V. Tugnoli
• Keywords: Parenchyma

Cholesteryl esters (CholE) were detected in human malignant neoplasms by means of vitro nuclear magnetic resonance spectroscopy. Spectroscopic analysis the total lipid extracts obtained from cerebral tumors revealed appreciable amount esterified cholesterol high grade gliomas such as glioblastomas and anaplastic oligodendrogliomas, characterized prominent neovascularity. The finding that no CholE healthy brain low benign supports a possible correlation between this class lipids histological vascular proliferation. Compared with gliomas, renal cell carcinomas show higher levels CholE, absent parenchyma oncocytomas. In nefro-carcinomas, cytoplasmic inclusions vascularization contribute to increased present mainly oleate. are discussed potential biochemical markers cancer target for new therapeutic strategies.