Interleukin-13 peptide kinoid vaccination attenuates allergic inflammation in a mouse model of asthma

• DOI: 10.3892/ijmm.2012.1036
• Publication Date: 2012-06-19T10:12:02Z
• Authors: QIUPING JING; TAO YIN; YANG WAN; HUASHAN SHI; SHUNTAO LUO; MENG LI; HAILONG ZHANG; HONG HE; SHIJIA LIU; HAOYU LI; YUQUAN WEI; LI YANG
• Keywords: Keyhole limpet hemocyanin; Immunogen

Asthma is an atopic disorder with increasing frequency and severity in developed nations. Interleukin-13 (IL-13) one of the most critical mediators asthma pathology. In present study, we a vaccine comprised keyhole limpet hemocyanin-mIL-13 heterocomplex immunogen to persistently neutralize excessive endogenous IL-13. Our results showed that IL-13 peptide kinoid could induce sustained high titer IL-13-specific IgG when using aluminum hydroxide as adjuvant, suppress accumulation eosinophils well levels bronchoalveolar lavage fluid (BALF). addition, total IgE ovalbumin (OVA)-specific serum were significantly inhibited. This study also vaccination prevent airway inflammation epithelial cell proliferation goblet hyperplasia mouse model acute asthma. summary, our findings suggest can serve innovative effective against