Antiviral activity of ginseng extract against respiratory syncytial virus infection

• DOI: 10.3892/ijmm.2014.1750
• Publication Date: 2014-04-22T11:06:19Z
• Authors: JONG SEOK LEE; EUN-JU KO; HYE SUK HWANG; YU-NA LEE; YOUNG-MAN KWON; MIN-CHUL KIM; SANG-MOO KANG
• Keywords: Mice, Inbred BALB C; 0303 health sciences; Cell Survival; Interleukin-6; Plant Extracts; Interleukin-8; Administration, Oral; Panax; Epithelial Cells; Articles; Dendritic Cells; Respiratory Mucosa; Antiviral Agents; Cell Line; 3. Good health; Interferon-gamma; Mice; 03 medical and health sciences; Host-Pathogen Interactions; Animals; Humans; Female; Reactive Oxygen Species; Lung

Panax ginseng has been known to have a number of immuno-modulatory effects. In this study, we investigated whether Korean red extract (KRGE) in vitro and vivo antiviral effects on respiratory syncytial virus (RSV) infection. KRGE improved the survival human lung epithelial cells against RSV infection inhibited replication. addition, treatment suppressed expression RSV-induced inflammatory cytokine genes (IL-6 IL-8) formation reactive oxygen species cell cultures. Oral administration mice with resulted lowering viral loads after Additionally, showed an enhanced level interferon-γ (IFN-γ) producing dendritic subsequent Taken together, these results suggested that activity