Global gene expression analysis combined with a genomics approach for the identification of signal transduction networks involved in postnatal mouse myocardial proliferation and development

• DOI: 10.3892/ijmm.2017.3234
• Publication Date: 2017-11-03T06:30:09Z
• Authors: Ruoxin Wang; Chao Su; Xinting Wang; Qiang Fu; Xingjie Gao; Chunyan Zhang; Jie Yang; Xi Yang; Minxin Wei
• Keywords: CDC20

Mammalian cardiomyocytes may permanently lose their ability to proliferate after birth. Therefore, studying the proliferation and growth arrest of during postnatal period enhance current understanding regarding this molecular mechanism. The present study identified differentially expressed genes in hearts obtained from 24 h‑old mice, which contain proliferative cardiomyocytes; 7‑day‑old are undergoing a burst; 10‑week‑old growth‑arrested cardiomyocytes, using global gene expression analysis. Furthermore, myocardial were analyzed numerous perspectives, including Gene Ontology annotation, cluster analysis, pathway enrichment network construction. results analysis indicated that, with increasing age, enriched function was not only associated cell cycle, division mitosis, but also metabolic processes protein synthesis. In ‘cell cycle’, pathways, such as ‘PI3K‑AKT signaling pathway’, ‘metabolic pathways’ well represented. Notably, revealed that bone morphogenetic (BMP)1, BMP10, cyclin E2, E2F transcription factor 1 insulin like exhibited increased mice. addition, signal transduction cycle identified. primarily focused on altered expression, downregulated anaphase promoting complex subunit 1, (CDC20), dependent kinase MYC proto-oncogene, bHLH CDC25C, upregulated DNA damage inducible α 10-week group, serve important roles arrest. conclusion, these data provide information development.