Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells.

• DOI: 10.3892/ijo.17.6.1151
• Publication Date: 2014-03-10T07:26:21Z
• Authors: J Yatsunami; S Aoki; Y Fukuno; Y Kikuchi; M Kawashima; S I Hayashi
• Keywords: Tranilast; Lewis lung carcinoma

We examined the effects of tranilast on tumor angiogenesis, growth and metastasis in mouse Lewis lung carcinoma C57BL system. Tranilast significantly reduced dense capillary network induced by cancer cells a dorsal air sac angiogenesis model. Intraperitoneal administration at 200 mg/kg/day size to about 63% that control suppressed pulmonary spontaneous Immunohistochemistry revealed vascularity increased apoptosis vivo. potentiated inhibition cyclophosphamide, cis-diamminedichloroplatinum(II), adriamycin vindesine These results suggest has antiangiogenic antitumor might have possible therapeutic applications.