Antiangiogenic and antitumor effects of tranilast on mouse lung carcinoma cells.

Male O-(Chloroacetylcarbamoyl)fumagillol Lung Neoplasms Neovascularization, Pathologic Vindesine Carcinoma Angiogenesis Inhibitors Antineoplastic Agents Apoptosis 3. Good health Mice, Inbred C57BL Mice 03 medical and health sciences 0302 clinical medicine Cyclohexanes Doxorubicin Tumor Cells, Cultured Animals Cisplatin Drug Screening Assays, Antitumor Cyclophosphamide Sesquiterpenes Neoplasm Transplantation
DOI: 10.3892/ijo.17.6.1151 Publication Date: 2014-03-10T07:26:21Z
ABSTRACT
We examined the effects of tranilast on tumor angiogenesis, tumor growth and metastasis in the mouse Lewis lung carcinoma and C57BL mouse system. Tranilast significantly reduced the dense capillary network induced by Lewis lung cancer cells in a mouse dorsal air sac angiogenesis model. Intraperitoneal administration of tranilast at 200 mg/kg/day reduced the tumor size of mouse Lewis lung carcinoma to about 63% of that of the control and suppressed pulmonary metastasis in a spontaneous system. Immunohistochemistry revealed that tranilast reduced the tumor vascularity and increased apoptosis of the tumor cells in vivo. Tranilast potentiated the inhibition of the tumor growth induced by cyclophosphamide, cis-diamminedichloroplatinum(II), adriamycin and vindesine in vivo. These results suggest that tranilast has antiangiogenic and antitumor effects and might have possible therapeutic applications.
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