The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells

• DOI: 10.3892/ijo.2012.1743
• Publication Date: 2012-12-18T07:26:54Z
• Authors: YUNLI LAI; XUERONG ZHANG; ZHENBO ZHANG; YUYAN SHU; XIAOLING LUO; YONGBIN YANG; XIAOJIE WANG; GUOPING YANG; LINXIA LI; YOUJI FENG
• Keywords: Survivin

Previously, we demonstrated that follicle stimulating hormone (FSH) enhanced VEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signaling pathway. In this study, further investigated involvement of microRNA-27a: ZBTB10‑specificity protein pathway in mechanism FSH-induced VEGF, Cox2 survivin expression. Treatment with FSH resulted significant increase Cox2, survivin, Sp1 proteins microRNA-27a a dose-dependent manner, whereas reverse pattern was observed ZBTB10. Downregulation using antisense blocked Overexpression ZBTB10 also attenuated these molecules. The abolished by knocking down small interfering RNA. Collectively, results indicated stimulation cell involves microRNA‑27a: ZBTB10-specificity