MicroRNA-126 modulates the tumor microenvironment by targeting calmodulin-regulated spectrin-associated protein 1 (Camsap1)

• DOI: 10.3892/ijo.2014.2321
• Publication Date: 2014-03-05T08:38:02Z
• Authors: XIN SUN; ZHI-MING WANG; YAN SONG; XU-HUI TAI; WEN-YUE JI; HUI GU
• Keywords: Male; 0303 health sciences; Mice, Nude; Neoplasms, Experimental; Middle Aged; Prognosis; Microtubules; 3. Good health; Gene Expression Regulation, Neoplastic; Mice; MicroRNAs; 03 medical and health sciences; Cell Line, Tumor; Carcinoma, Squamous Cell; Tumor Microenvironment; Animals; Humans; Female; Neoplasm Metastasis; Laryngeal Neoplasms; Microtubule-Associated Proteins; Phylogeny

Plasma miRNAs have been reported as biomarkers for various diseases. In this study, we investigated whether plasma concentrations of miR-126 may be useful laryngeal squamous cell carcinoma (LSCC). We examined the function and mechanism in LSCC by using biology molecular pathology techniques such western blotting, quantitative PCR, IHC IF. The expression Camsap1 mRNA protein is higher cancer tissues compared to that normal tissues. Both were related with prognosis patients. found was able inhibit partly suppressing expression. addition, induced microtubule formation aggregation. This possibly explains why loss frequently associated tumor metastasis.