miR-382 inhibits migration and invasion by targeting ROR1 through regulating EMT in ovarian cancer

• DOI: 10.3892/ijo.2015.3241
• Publication Date: 2015-11-09T13:42:31Z
• Authors: HONG TAN; QINGNAN HE; GUANHUI GONG; YIXUAN WANG; JUANNI LI; JUNPU WANG; DING ZHU; XIAOYING WU
• Keywords: ROR1

Increasing evidence suggests that microRNAs (miRNAs) play a critical role in tumorigenesis. Decreased expression of miR‑382 has been observed various types cancers. However, the biological function miRNA-382 ovarian cancer is still largely unknown. Here, we found was downregulated human tissues and cell lines. inhibited proliferation, migration, invasion epithelial-mesenchymal transition (EMT). Furthermore, identified receptor tyrosine kinase orphan 1 (ROR1) as target miR‑382, rescued promotion effect ROR1 on EMT process SKOV3 COV434 cells. Collectively, these findings revealed inhibits migration invision by targeting through regulating cancer, might serve tumor suppressor cancer.