Curcumin inhibits cell proliferation and motility via suppression of TROP2 in bladder cancer cells

• DOI: 10.3892/ijo.2018.4423
• Publication Date: 2018-05-30T12:32:35Z
• Authors: Lianhua Zhang; Guoliang Yang; Ruiyun Zhang; Liang Dong; Haige Chen; Juanjie Bo; Wei Xue; Yiran Huang
• Keywords: Oncogene Proteins; 0303 health sciences; Curcumin; Dose-Response Relationship, Drug; Cell Survival; Down-Regulation; Antineoplastic Agents; Articles; Cell Cycle Checkpoints; 3. Good health; Gene Expression Regulation, Neoplastic; 03 medical and health sciences; Urinary Bladder Neoplasms; Antigens, Neoplasm; Cell Movement; Cell Line, Tumor; Proliferating Cell Nuclear Antigen; Cyclin E; Humans; Cell Adhesion Molecules; Cell Proliferation

Bladder cancer (BC) has become a serious health prob-lem and represents the second most commonly diagnosed urological tumor. Curcumin is principal active natural component of turmeric long been used in Asia as traditional herbal medicine. suppresses cell growth various types cancer, including BC, by regulating numerous molecular signaling pathways. The human trophoblast surface antigen 2 (Trop2) belongs to tumor-associated calcium signal transducer gene family. Trop2 described driver deregulated cancer. However, whether involved curcumin-induced BC inhibition remains be elucidated. present study hypothesized that may promising target curcumin cells. It was found closely proliferation suppression, mobility inhibition, apoptosis, cycle arrest decreased expression its downstream cyclin E1, increased level p27. overexpression enhanced oncogenic activity cells, whereas downregulation suppressed mobility, sensitized cells treatment. Therefore, an important method for therapeutic management patients with BC.