The emerging roles of CEACAM6 in human cancer (Review)

• DOI: 10.3892/ijo.2024.5615
• Publication Date: 2024-01-18T07:43:53Z
• Authors: Guanhua Wu; Da Wang; Fei Xiong; Qi Wang; Wenzheng Liu; Junsheng Chen; Yongjun Chen
• Keywords: Tumor progression

Carcinoembryonic antigen (CEA)‑related cell adhesion molecule 6 (CEACAM6) is a protein of the CEA family glycosyl phosphatidyl inositol anchored surface glycoproteins. A wealth research has demonstrated that CEACAM6 generally upregulated in pancreatic adenocarcinoma, breast cancer, non‑small lung gastric colon cancer and other cancers promotes tumor progression, invasion metastasis. The transcriptional expression regulated by various factors, including CD151/TGF‑β1/Smad3 axis, microRNA (miR)‑146, miR‑26a, miR‑29a/b/c, miR‑128, miR‑1256 DNA methylation. In addition, N‑glycosylation at Asn256 mediated α‑1,6‑mannosylglycoptotein 6‑β‑N‑acetylglucosaminyltransferase. terms downstream signaling pathways, proliferation increasing levels cyclin D1 cyclin‑dependent kinase 4 proteins. can activate ERK1/2/MAPK or SRC/focal kinase/PI3K/AKT pathways directly through EGFR, leading to stimulation proliferation, invasion, migration, resistance anoikis chemotherapy, as well angiogenesis. This article provides review pattern, biological function relationship with prognosis cancer. summary, may be valuable diagnostic biomarker potential therapeutic target for human exhibiting overexpression CEACAM6.