S100 protein family: Emerging role and mechanism in digestive tract cancer (Review)

• DOI: 10.3892/ijo.2024.5647
• Publication Date: 2024-04-24T07:05:36Z
• Authors: Mingshuai Li; Peng Cui; Wenqing Dai; Bo Cao; Haobin Zhao; Shuyu Jin; Donghua Xu; Youkui Shi; Shushan Yan
• Keywords: Gene Expression Regulation, Neoplastic; Epithelial-Mesenchymal Transition; Neovascularization, Pathologic; S100 Proteins; Biomarkers, Tumor; Tumor Microenvironment; Humans; Prognosis; Cell Proliferation; Gastrointestinal Neoplasms

Digestive tract cancer is one of the most common types cancers globally, with ~4.8 million new cases and 3.4 cancer‑associated deaths in 2018, accounting for 26% incidence 35% cancer‑related worldwide. S100 protein family involved regulating cell proliferation, angiogenesis, epithelial‑mesenchymal transition (EMT), metastasis, metabolism immune microenvironment homeostasis. The critical role digestive involves complicated mechanisms, such as stemness remodeling, anaerobic glycolysis regulation, tumor‑associated macrophage differentiation EMT. present study systematically reviewed published studies on compositions, function underlying molecular mechanisms family, well guidance diagnosis, treatment prognosis cancer. Systematic review roles may provide insight into exploring potential biomarkers optimized therapeutic strategies