EXPRESSION MECHANISM OF HUMAN UTERINE ENDOMETRIAL CANCER-SPECIFIC FUCOSYLATED CARBOHYDRATE CHAINS - ABERRANT ALPHA-1-]4-FUCOSYL-TRANSFERASES IN UTERINE ENDOMETRIAL CANCER-DERIVED CELL-LINES WITH TYPE-I CARBOHYDRATE CHAIN

• DOI: 10.3892/ijo.6.1.93
• Publication Date: 2014-03-10T03:21:12Z
• Authors: K KUBUSHIRO; K TSUKAZAKI; Y SAKUMA; Y AKIBA; M SAKAYORI; R AOKI; S YAZAWA; S NOZAWA
• Keywords: 03 medical and health sciences; 0302 clinical medicine; 3. Good health

Cells of uterine endometrial cancer cell line SNG-II were classified into two groups according to their reactivity with anti-uterine endometrial cancer monoclonal antibody (MSN-1), whose recognition antigen is mainly the Lewis(b) antigens; those that strongly reacted with MSN-1 (SNG-S group) and those that weakly reacted with it (SNG-W group). The SNG-S showed a higher activity of a 1-->4-fucosyltransferase activity than that of the SNG-W. The expression of Lewis(b) antigen was stronger in the SNG-S than that in the SNG-W. Therefore, the expression of uterine endometrial cancer-specific fucosylated carbohydrate could be mainly controlled by alpha-fucosyltransferase activities.