Main complications and results of treatment with intra-arterial infusion chemotherapy through the subclavian and thoracic arteries for locally advanced breast cancer

• DOI: 10.3892/mco.2013.129
• Publication Date: 2013-05-23T10:43:16Z
• Authors: XIAOYI WANG; CHANGING GAN; HONGYUAN LI; YUXIAN WEI; DONCHANG ZHU; GUANGLUN YANG; XINLIANG SU; JEAN-FRANÇOIS RODIER; GUOSHENG REN
• Keywords: Axillary artery

Intra‑arterial infusion chemotherapy for locally advanced breast cancer (LABC) has been previously performed. However, the main complications of this type remain to be clarified. In present study, catheterization was carried out 53 LABC cases (stage Ⅲa-Ⅲc) between May, 2006 and March, 2007. For ⅢB ⅢC patients, catheters were guided opening subclavian artery. stage Ⅲa placed into thoracic artery through a subcutaneous femoral puncture. One four cycles (mean, 1.6 cycles) administered patients using taxotere, epidoxorubicin, 5-fluorouracil and/or cyclophosphamide. The interval time two 21 days. Seven identified as complete response (CR, 13.2%), 41 partial (PR, 77.4%) with rate effectiveness (CR + PR, 90.6%), 5 stable disease (SD, 9.40%) no case progressive. Pain ipsilateral upper extremity in 7 cases. Two exhibited atrophy following drug administration from experienced neck pain headache, while one necrosis local skin evident. Hematological toxicity over grade 3 observed 6 (11.30%). Systemic mild did not affect quality life patients. Overall survival 18/51 (35.3%), free‑disease 10/51 (19.6%). conclusion, intra-arterial is an effective control treatment LABC. are well headache. Severe skin. During treatment, controlling pressure tourniquet velocity crucial reducing complications.