Prognostic value of tumor‑infiltrating lymphocytes in estrogen receptor‑positive and human epidermal growth factor receptor 2‑negative breast cancer

• DOI: 10.3892/mco.2021.2414
• Publication Date: 2021-10-08T10:56:43Z
• Authors: Chikako Honda; Sasagu Kurozumi; Ayaka Katayama; Bishoy Hanna‑Khalil; Kei Masuda; Yuko Nakazawa; Misato Ogino; Sayaka Obayashi; Reina Yajima; Takaya Makiguchi; Tetsunari Oyama; Jun Horiguchi; Ken Shirabe; Takaaki Fujii
• Keywords: Tumor-infiltrating lymphocytes; Triple-negative breast cancer; Progesterone receptor

Tumor-infiltrating lymphocytes (TILs) are a significant prognostic factor in triple-negative breast cancer. However, the clinicopathological significance of TILs estrogen receptor (ER)-positive and human epidermal growth 2 (HER2)-negative cancer remains unclear. The purpose present study was to evaluate role prognosis ER-positive HER2-negative A total 65 consecutive patients with were examined. stromal tissue (str-TILs) graded using International Working Group criteria. association between several factors TIL grade investigated, impact compared luminal A-like B-like 51 (78.5%) had low-grade (0-10%), 11 (16.9%) intermediate (10-40%) 3 (4.6%) high-grade (40-90%) str-TIL levels. There high levels Ki67 expression count. Relapse-free survival significantly worse that Patients an or count better those low All developed no recurrence during follow-up. In conclusion, there correlation tumor cell proliferation rate, as well expression.