Association between high‑density lipoproteins and prostate specific antigen: A cross‑sectional study from NHANES database

• DOI: 10.3892/mco.2025.2829
• Publication Date: 2025-02-18T08:24:56Z
• Authors: Mohamed Adan; Bowen Hu; Minbo Yan; Sakarie Hidig; Yingbo Dai; Gonghui Li
• Keywords: Cross-sectional study

According to increasing evidence, high-density lipoproteins (HDLs) may raise prostate-specific antigen (PSA) levels in the prostate. The link between HDL-cholesterol (C) and PSA, on other hand, is debatable challenging. Hence, present study examined relationship HDL-C PSA men using National Health Nutrition Examination Survey (NHANES) database. NHANES data were extracted for five cycles from 2001 2010. used analysis included concentrations, sociodemographic laboratory data. After screening, 6,669 out of 52,195 participants study. Participants divided into four groups based quartiles. Categorical continuous variables weighted chi-square tests linear regression models analysed compare differences groups. A total three multivariate constructed association a smoothed curve fit was assessed. In study, unadjusted adjusted revealed significant positive concentrations serum levels. Specifically, each unit increase ratio associated with an concentration by 0.470 ng/ml (P<0.001) model. minimally models, accounting socioeconomic demographic factors, this remained significant, 0.408 per (P<0.001). Furthermore, stratified various impacts status levels, interaction household income (P=0.037). Exclusion subjects low strengthened association, revealing higher (0.50 1 mmol/l increase, P=0.009). findings suggest nuanced highlighting potential importance considering these factors prostate cancer (Pca) screening risk assessment. found adult United States without Pca diagnosis.